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ΔFos B is the most significant factor involved in both amphetamine addiction and amphetamine-induced sex addictions, which are compulsive sexual behaviors that result from excessive sexual activity and amphetamine use.

Both methamphetamine and dextromethamphetamine are illicitly trafficked and sold owing to their potential for recreational use.Methamphetamine is known to possess a high addiction liability (i.e., a high likelihood that long-term or high dose use will lead to compulsive drug use) and high dependence liability (i.e.a high likelihood that withdrawal symptoms will occur when methamphetamine use ceases).Heavy recreational use of methamphetamine may lead to a post-acute-withdrawal syndrome, which can persist for months beyond the typical withdrawal period.Unlike amphetamine, methamphetamine is neurotoxic to human midbrain dopaminergic neurons.

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